https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19242 Wed 11 Apr 2018 12:53:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29794 Thu 04 Nov 2021 10:39:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20454 Sat 24 Mar 2018 08:06:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17131 Sat 24 Mar 2018 08:02:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17278 Sat 24 Mar 2018 08:01:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20130 Sat 24 Mar 2018 07:51:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21347 Sat 24 Mar 2018 07:51:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28484 Davidsonia pruriens F. Muell) and to assess the physicochemical and antioxidant properties of the phenolic-enriched extract. The results showed that temperature, time and ratio significantly affected the extraction of TPC. Optimization of extraction conditions was performed using response surface methodology (RSM) utilising a Box–Behnken design. Optimal extraction conditions were determined to be temperature: 90 °C, extraction time: 30 min and solvent to mass ratio: 20:1 mL g⁻¹. The extracted solid obtained under these conditions had low-moisture content, high water solubility and contained 45 mg GAE g−1 of TPC, 22 mg RUE g⁻¹ of flavonoids, 3.2 mg CAE g⁻¹ of proanthocyanidins, 2 mg CGE g⁻¹ of anthocyanidins and 56 mg ACE g⁻¹ vitamin C. The extract possessed potent antioxidant capacity, but was comparatively lower than those of vitamin E and BHT. Thus, Davidson's plum should be further investigated for its potential health promoting benefits and utilisation in the nutraceutical and food industries.]]> Sat 24 Mar 2018 07:39:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27971 0.05) influenced by time and temperature, compared with controls. Drying conditions of 65°C for 120 min are recommended for optimization of drying.]]> Sat 24 Mar 2018 07:38:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27329 Eucalyptus robusta (Sm.) (ER) is a widely distributed tree native to the east coast of Australia, which has also been established in numerous other countries. ER leaves contain high levels of essential oils and are rich in total phenolic compounds (TPC), which have been linked with health benefits; however, there is limited information on the bioactivity of ER leaf extracts. This study aimed to optimise water extraction conditions for TPC, prepare a spray-dried powdered extract and test its physicochemical, antioxidant and anti-proliferative properties. The results showed that optimal water extraction conditions for TPC were 85°C, 15 min and a water-to-leaf ratio of 20:1 mL/g. Under these conditions, spray-dried powdered extract was prepared with a recovery yield of 85%. The extract was water-soluble and had a TPC level of 407 mg GAE/g. It also possessed potent antioxidant capacity, comparable to pure ascorbic acid, but higher than pure α-tocopherol. In addition, the powdered extract demonstrated significant activity against a panel of cancer cell lines, which included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Of note, the ER extract exerted a more significant toxic effect on pancreatic cancer (PC) cells compared to gemcitabine, the first line chemotherapeutic agent for PC. We suggest that future studies should purify individual bioactive compounds from ER for further investigation of its potential health promoting and anti-cancer activity.]]> Sat 24 Mar 2018 07:38:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25688 Sat 24 Mar 2018 07:28:23 AEDT ]]>